Hehnly Lab has a paper at Molecular Biology of the Cell!

by Heidi Hehnly in


Colicino et al. talks about the role of Gravin anchoring PLK1 at mitotic centrosomes. This anchor is important for regulating centrosome organization and function as seen below with super resolution imaging of the centrosome component CEP215 disorganization when Gravin is lost. 

A panel taken from Figure 4 from Colicino et al. of CEP215 disorganization primarily at a single mitotic spindle pole with Gravin loss.  We argue this is through uncontrolled phosphorylation of CEP215 by PLK1 in the absence of Gravin.

A panel taken from Figure 4 from Colicino et al. of CEP215 disorganization primarily at a single mitotic spindle pole with Gravin loss.  We argue this is through uncontrolled phosphorylation of CEP215 by PLK1 in the absence of Gravin.


ASCB 2016 in San Francisco

by Heidi Hehnly in ,


Lindsay Rathbun and Erica Colicino did a great job this year presenting their work at ASCB in San Francisco!  Erica talked about her study on the spatial and temporal regulation of the mitotic kinase Plk1 and Lindsay presented her work on the role of division orientation during 3D expansion and embryonic patterning. 

Lindsay Rathbun presenting her talk titled "The role of division orientation in tissue patterning".  This is a collaborative project between our lab (Hehnly Lab) and the Amack Lab at SUNY Upstate.

Lindsay Rathbun presenting her talk titled "The role of division orientation in tissue patterning".  This is a collaborative project between our lab (Hehnly Lab) and the Amack Lab at SUNY Upstate.

Erica Colicino presenting her poster titled "Plk1 spatial synchronization and activity during mitosis." This is a collaborative project between our lab (Hehnly Lab) and Leszek Kotula's laboratory at SUNY Upstate Medical University. 

Erica Colicino presenting her poster titled "Plk1 spatial synchronization and activity during mitosis." This is a collaborative project between our lab (Hehnly Lab) and Leszek Kotula's laboratory at SUNY Upstate Medical University.