The Hehnly Lab’s 1st preprint, led by Lindsay Rathbun with the help of many people including our graduate student Abrar Aljiboury and postbac Julie Manikas, along with Josh Bembenek’s laboratory (University of Michigan with X Bai from the NIH) and Jeff Amack’s laboratory (UPSTATE Medical School, Syracuse NY). We found some crazy large centrosomes in extremely large zebrafish embryo cells that scale with changes in cell size! We didn’t leave out C. elegans either. Check it out here:
Boryana, Ed, and I thought what better way to relax than chat about some art and biology. I know I can use something positive and fun to think about, so why not virtually get together and listen to bio-artist Kira O’Reily and biologist Margaret McCoy talk about their work. Ed Morris will be moderating discussion where you can ask questions in the chat or live via zoom. We can’t offer snacks as usual, but you can bring your own and I will raise a glass to toast our excellent speakers and friends who can make it. Please spread the word.
Kira O’Reily is an Artist and Lecturer based out of Helsinki, Finland. Visit her website here: https://about.me/kira_oreilly and her presentation will focus on menopause, where she will create a discussion around the affects of hormone and endocrine systems across bodies, species, and environments.
Margaret McCoy is a graduate student in Melissa Pepling’s laboratory (http://peplinglab.syr.edu/index.html) and will be discussing how general anesthetics affect reproductive organ function and cognitive behavior.
We had a great winter to spring rotation with Peter Raymond-Smiedy in the lab! He worked on Cenexin’s role as a scaffold for the mitotic kinase, Polo Like Kinase 1 (PLK1) where he got to perform some sweet microscopy and live cell imaging. He even did our first virtual lab meeting on zoom!
Peter worked closely with our lab postbac scholar Michael Bates (on left in photo below) where they created with the help of Judy Freshour (lab manager) a CRISPR cenexin-null line. Way to go Peter and Mike!
Peter on right, and Mike Bates on left out celebrating Lindsay’s successful Ph.D. defense (before COVID-19)
Our paper is out! This study was lead by Lindsay Rathbun with many major contributions from past and current lab members and our collaborators Lisa Manning (SU) and Jeffrey Amack (SUNY Upstate). Its a really cool study demonstrating that the final step in cell division, cytokinesis and abscission, is needed for the lumen to form in the zebrafish left-right organizer. This transient tissue goes from a series of mesenchymal like migratory cells that divide and transition into polarized epithelial cells. Our team proposes a model that division assists in this process and the cytokinetic bridge, which can stay around for up to an hour, helps hold the cells in a transient rosette structure before they can initiate lumen formation. Check the paper out here at Nature Communications.
In cyan is a dividing cell interconnected by a cytokinetic bridge that is about to undergo abscission. Once the bridge abscises you can see the KV lumen open up! Magenta is labeling KV cells plasma membrane.
