Paula Bucko, a graduate student in John Scott (Pharmacology, UW), recently published an exciting study titled “Subcellular drug targeting illuminates local kinase action.” We (primarily Lindsay Rathbun, Hehnly lab graduate student and myself) were super excited to help Paula and John out with doing the zebrafish/in vivo studies featured in the paper that shows a novel chemical genetic approach to spatially and temporally inhibit the mitotic kinase PLK1.
You can read the study here and a cool digest here.
zebrafish expressing the SNAP-PACT (magenta) for centrosomal targetted PLK1 inhibition during zebrafish embryonic development.
Lindsay Rathbun (graduate student), Jessica O’Connell (graduate student), Nikhila Krishnan (graduate student), and Julie Manikas (postbac) all did a great job mixing with scientists and presenting their work at ASCB! Julie Manikas gave a talk to a packed room on cilia formation in the developing zebrafish embryo and the rest of the lab gave poster presentations on centrosome signaling, membrane trafficking, forces required to create a tissue, and cell division during embryogenesis. I even had a guest presenter to present my poster on PLK1 activity at the centrosome, Hehnly Lab Alumni Erica Colicino!
Erica Colicino (Hehnly Lab Alum) presenting on cenexin and PLK1
Julie Manikas presenting on Cilia formation in the developing embryo
Jessica O’Connel presenting on the role of the cytokinesis bridge in Rosette formation.
Lindsay Rathbun presenting her work on the role of the Cytokinetic bridge in lumen formation.
Nikhila presenting on the role of endosomes and the centrosome during cell division.
We also enjoyed a great dinner with collaborators and old friends! It was awesome to hang out with Julia Riley from the Castaneda lab, Hui-Fang Hung and Ana Vertii, old friends from the Doxsey Lab, and Colleen McDowell (Wisconsin).
Julia Riley, Erica Colicino, Heidi Hehnly, and Julie Manikas
Due to the environment on campus, and in support of the Syracuse University student protests and their requests from the University we have decided to cancel The BioArt Mixer till further notice. We hope that everyone stays safe.
As a faculty member in the Biology Department, I denounce these hateful acts and stand with the students protesting for change at the University.
Abrar, Lindsay, Julie, and Nikhila did a great job giving oral talks in the morning on the role of cell division, the centrosome, endosomes, and cilia in tissue morphogenesis! Following the talks were posters from Michael, Jess, Michelle, and Nicole. Great job Hehnly Lab!
