The latest Hehnly Lab preprint was featured by preLights! Check out the great write up by Maiko Kitaoka and Q&A with Lindsay Rathbun.
You can visit the preLights article here.
Check out our new Preprint!
The Hehnly Lab’s 1st preprint, led by Lindsay Rathbun with the help of many people including our graduate student Abrar Aljiboury and postbac Julie Manikas, along with Josh Bembenek’s laboratory (University of Michigan with X Bai from the NIH) and Jeff Amack’s laboratory (UPSTATE Medical School, Syracuse NY). We found some crazy large centrosomes in extremely large zebrafish embryo cells that scale with changes in cell size! We didn’t leave out C. elegans either. Check it out here:
Also check out a zebrafish embryo dividing cells! Microtubules (EMTB-GFP) on left and centrosomes (centrin-GFP) on right.
Cytokinetic bridge triggers de novo lumen formation in vivo.
Our paper is out! This study was lead by Lindsay Rathbun with many major contributions from past and current lab members and our collaborators Lisa Manning (SU) and Jeffrey Amack (SUNY Upstate). Its a really cool study demonstrating that the final step in cell division, cytokinesis and abscission, is needed for the lumen to form in the zebrafish left-right organizer. This transient tissue goes from a series of mesenchymal like migratory cells that divide and transition into polarized epithelial cells. Our team proposes a model that division assists in this process and the cytokinetic bridge, which can stay around for up to an hour, helps hold the cells in a transient rosette structure before they can initiate lumen formation. Check the paper out here at Nature Communications.
In cyan is a dividing cell interconnected by a cytokinetic bridge that is about to undergo abscission. Once the bridge abscises you can see the KV lumen open up! Magenta is labeling KV cells plasma membrane.
Check out the Hehnly Lab's Newest Paper in Molecular Biology of the Cell! And, we got the cover!!!
Our studied title “ Chromosome misalignment is associated with PLK! activity at cenexin-positive mitotic centrosomes” is now officially published. Check it out here. This project was led by the Hehnly lab’s graduate student Erica Colicino who now is at University of Michigan doing her postdoctoral work with Puck Ohi’s lab. Erin Curtis a postbac scholar in the Hehnly lab and now a graduate student at Duke designed the cover that was selected and made major contributions to the study.
