Subcellular drug targeting illuminates local kinase action
Paula Bucko, a graduate student in John Scott (Pharmacology, UW), recently published an exciting study titled “Subcellular drug targeting illuminates local kinase action.” We (primarily Lindsay Rathbun, Hehnly lab graduate student and myself) were super excited to help Paula and John out with doing the zebrafish/in vivo studies featured in the paper that shows a novel chemical genetic approach to spatially and temporally inhibit the mitotic kinase PLK1.
zebrafish expressing the SNAP-PACT (magenta) for centrosomal targetted PLK1 inhibition during zebrafish embryonic development.
Bergstralh and Hehnly Mitosis Club (3rd one!)
The Bergstralh and Hehnly Lab Mitosis Club was super fun and held at University of Rochester yesterday. Our lab learned a bunch about cell-cell adhesions and their remodeling during division from Dan’s group. There was great stories about 3-D stem culture models, Drosophila models, and from our lab zebrafish and human tissue culture cells. We saw some beautiful STED micrographs and prelim laser ablation studies. I can’t wait for the next one! Those that attended from the Hehnly Lab were Julie, Nikhila, Heidi, Lindsay, and Jessica.
Hehnly and Bergstralh Mitosis Club! June 2019
A beautiful study from the Castaneda lab!
Erica Colicino in the Hehnly Lab was excited to contribute to the Castaneda’s lab study on “ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner”.
Definitely check it out!
