Paula Bucko, a graduate student in John Scott (Pharmacology, UW), recently published an exciting study titled “Subcellular drug targeting illuminates local kinase action.” We (primarily Lindsay Rathbun, Hehnly lab graduate student and myself) were super excited to help Paula and John out with doing the zebrafish/in vivo studies featured in the paper that shows a novel chemical genetic approach to spatially and temporally inhibit the mitotic kinase PLK1.
You can read the study here and a cool digest here.
zebrafish expressing the SNAP-PACT (magenta) for centrosomal targetted PLK1 inhibition during zebrafish embryonic development.
The Bergstralh and Hehnly Lab Mitosis Club was super fun and held at University of Rochester yesterday. Our lab learned a bunch about cell-cell adhesions and their remodeling during division from Dan’s group. There was great stories about 3-D stem culture models, Drosophila models, and from our lab zebrafish and human tissue culture cells. We saw some beautiful STED micrographs and prelim laser ablation studies. I can’t wait for the next one! Those that attended from the Hehnly Lab were Julie, Nikhila, Heidi, Lindsay, and Jessica.
The 5th Bio-Art Mixer hosted Suzanne Anker (SVA) and John Drake (ESF) this past Friday at the Everson Museum of Art. There was live music, beer, and even a Bio-Art work station for kids! It was a really great event and I can’t wait till our next one next semester. Included are pictures below.
