The two lives of the centrosome during the cell cycle (A) In interphase, the centrosome functions as a basal body for primary cilia formation. (B) The basal body matures into the spindle poles during mitosis. (C) The centrosome duplicates once per cell cycle, during S phase, and moves to opposite sides of the cell starting at G2 and throughout mitosis. In G0, the centrosome docks at the membrane and templates cilia formation once again.
Ana and Alison have just published a fun review talking about the role of cilia proteins outside of the cilia. Take a peak here: Vertii A et al. EMBO Reports.
Congrats to Edmarcia Elisa de Souza and all the affiliated authors at the University of Campinas, Brazil, on their accepted story entitled "Human Nek7-interactor RGS2 is required for mitotic spindle organization." It was fun to have the chance to work with Edmarcia while we were in the Doxsey Lab on this. Jorg Kobarg's group found that a cell cycle related kinase, Nek7, through its interaction with a regulator of G-protein signaling, RGS2, has an exciting new implication in spindle orientation and spindle pole maturation. Check it out! It's currently in press, but you can find a link to it through pub med or through Cell Cycle below:
Cell Cycle. 2015 Feb 9:0. [Epub ahead of print]
Human Nek7-interactor RGS2 is required for mitotic spindle organization.
Elisa de Souza E, Hehnly H, Perez AM, Vaz Meirelles G, Costa Smetana JH, Doxsey S, Kobarg J.