The lab was rewarded their first R01 this past month and we couldn't be happier. We are super excited to tackle the role of membrane trafficking during division and how the centrosome may direct that process!
How do ciliated cells utilize their REs and centrosomes to develop into a functional polarized organ? Shown is a model for how REs (green) organize at or around the centrosome (red) and target to the midbody (orange). Aim 1 will determine the spatial and temporal activity of Rab8 and Rab11 and the dependence of this activity on the centrosome. Aim 2 will address whether polarity is formed through RE-targeted vesicle transport during cytokinesis and maintained by spindle positioning.